Current Clinical Trials | ECHO Associates

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Current Trials

Genetic Risk Assessment

ECHO Open to Accrual Clinical Trials

Updated: 03/26/2023

Bladder / Urothelial

A Phase II Open-Label study of IMMU-132 in Metastatic Urothelial Cancer after failure of Platinum-Based regimen or Anti-PD-1/PD-L1 based Immunotherapy


GS-US-592-6173 / Ascent-04
A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan and Pembrolizumab Versus Treatment of Physician’s choice and Pembrolizumab in Patients with Previously Untreated, Locally Advanced, Inoperable, or Metastatic Triple-Negative Breast Cancer, whose Tumors Express PD-L1

GS-US-592-6238 / Ascent-03
A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan Versus Treatment of Physician’s Choice in Patients with Previously Untreated, Locally Advanced, Inoperable or Metastatic Triple-Negative Breast Cancer Whose Tumors Do Not Express PD-L1 or in Patients Previously Treated with Anti-PD(L)1 Agents in the Early Setting Whose Tumors do Express PD-L1

A Phase III, randomized, Open-Label, multicenter study evaluating the efficacy and safety of Giredestrant plus Everolimus compared with Exemestane plus Everolimus in patients with estrogen receptor-positive, HER2-Negative, locally advanced or Metastatic Breast Cancer



A Double-Blind, Placebo-Controlled, Randomized, Dose-Escalating, Multi-Center, Phase 1 Study to Assess the Safety and Tolerability of ART-123 in Combination with Leucovorin/5-Fluorouracil/Oxaliplatin and Bevacizumab in Metastatic Colorectal Cancer patients

Gritstone / GO-010
A Phase 2/3, randomized, Open-Label Study of Maintenance GRT-C901/GRT-R902, A Neoantigen Vaccine, in Combination with Immune Checkpoint Blockade for Patients with Metastatic Colorectal Cancer

MRT 849-010 / Krystal-10
A Randomized Phase 3 Study of MRTX849 in Combination with Cetuximab Versus Chemotherapy in Patients with Advanced Colorectal Cancer with KRAS G12C Mutation with Disease Progression On or After Standard First-Line Therapy


A Randomized, Double-Blind, International Multicenter, Phase III Study to Evaluate the Anti-Tumor Efficacy and Safety of HLX10 (Recombinant Humanized Anti-PD-1 Monoclonal Antibody Injection) or Placebo in Combination with Chemotherapy (Carboplatin/Cisplatin-Etoposide) and Concurrent Radiotherapy in Patients with Limited-Stage Small Cell Lung Cancer (LS-SCLC)

JZP 712-402
Emerge 402: Phase IV Observational Study to Collect Safety and Outcome data in Real-World Setting in Adult Patients with Extensive Stage Small Cell Lung Cancer (SCLC) Receiving Zepzelca

Alchemist Trials Adjuvant Trials for completely resected patients EGFR or ALK positive

Adjuvant Lung Cancer enrichment marker identification and sequencing trial (Alchemist)

A phase III double-blind trial for surgically resected early stage Non-Small Cell Lung cancer: Crizotinib versus Placebo for pateints with tumors harboring the Anaplastic Lymphoma Kinase (ALK) fusion protein

First Line Metastatic

GS-US-626-6216 / Star-121
A Randomized, Open-Label, Phase 3 Study to Evaluate Zimberelimaband Domvanalimab in Combination with Chemotherapy versus Pembrolizumab with Chemotherapy for the First-Line Treatment of Patients with Metastatic Non-Small Cell Lung Cancer with no Epidermal Growth Factor Receptor or Anaplastic Lymphoma Kinase Genomic Tumor Aberrations

Mirati 849-007
A Phase 2 Trial of MRTX849 in Combination with Pembrolizumab in Patients with Advanced non-Small Cell Lung Cancer with KRAS G12C Mutation

Second Line Metastatic

GSK 213410
A Randomized, Open Label Phase 2/3 Study Comparing Cobolimab + Dostarlimab + Docetaxel to Dostarlimab + Docetaxel to Docetaxel Alone in Participants with Advanced Nonsmall Cell Lung Cancer who have Progressed on Prior Anti PD (L)1 Therapy and Chemotherapy (Costar Lung)


D8227C00001 / ACE-LY-312 / Escalade
A phase 3, Randomized, Double-Blind, Placebo-controlled study of Acalabrutinib in combination with Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Subjects 65 years or younger with previously untreated Non-Germinal Center Diffuse Large B-Cell Lymphoma

LOXO-BTK-20030  ***Screening of treatment naïve patients is closed***
A Phase 3 Open-Label, Randomized Study of Pirtobrutinib (LOXO-305) versus Ibrutinib in Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN-CLL-314)


Study of EOS884448 alone, and in combination with Iberdomide with or without Dexamethasone, in participants with relapsed or refactory Multiple Myeloma

Prostate Cancer

AMPLITUDE / 67652000PCR3002
A Phase 3 Randomized, Placebo-controlled, Double-Blind Study of Niraparib in Combination with Abiraterone Acetate and Prednisone versus Abiraterone Acetate and Prednisone for the treatment of Participants with Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC).

Solid Tumors

JZP712-201 / Emerge-201
A Phase 2, Multicenter, Open-Label Study of Lurbinectedin Efficacy and Safety in Participants with Advanced or Metastatic Solid Tumors

PBI-200-101/TIME-Tempus Trial
A Phase 1-2 Study of PBI200 in Subjects with NTRK-Fusion-Positive Advanced or Metastatic Solid Tumors

Supportive Care

Bespoke (Natera)
BESPOKE Study of ctDNA Guided Immunotherapy

ESR 22-21698 (EIMPRIS)
Real World Evaluation of the Effectiveness of AZD7442 for Prevention of SARS-CoV-2 Infection in Immuno-Suppressed Cancer Patients

FRNM-008 (Freenome)
A Case Control Study for the Development of Multiomics Blood Test for Cancer Screening

THR-CS-001 / THRIVE / DETECT-ASCEND 2 ***Only Thyroid, Ovarian, Uterine and Bladder Cohorts Open***
Exact Sciences Thrive LLC / Detecting Cancers Earlier Through Elective Plasma-Based CancerSEEK Testing – Ascertaining Serial Cancer Patients to Enable New Diagnostic II (DETECT-ASCEND 2)

To learn about our newest study on biomarker testing, click here.

To learn about our newest study on bladder cancer, click here.

For more information on clinical trials, please contact Dr. Susan Johnson, Director of Research or 860-886-8362.