Current Clinical Trials | ECHO Associates

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Current Trials

Genetic Risk Assessment

ECHO Open to Accrual Clinical Trials

Updated: 09/13/2023

Bladder / Urothelial

A Phase II Open-Label study of IMMU-132 in Metastatic Urothelial Cancer after failure of Platinum-Based regimen or Anti-PD-1/PD-L1 based Immunotherapy


GS-US-592-6173 / Ascent-04
A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan and Pembrolizumab Versus Treatment of Physician’s choice and Pembrolizumab in Patients with Previously Untreated, Locally Advanced, Inoperable, or Metastatic Triple-Negative Breast Cancer, whose Tumors Express PD-L1

GS-US-592-6238 / Ascent-03
A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan Versus Treatment of Physician’s Choice in Patients with Previously Untreated, Locally Advanced, Inoperable or Metastatic Triple-Negative Breast Cancer Whose Tumors Do Not Express PD-L1 or in Patients Previously Treated with Anti-PD(L)1 Agents in the Early Setting Whose Tumors do Express PD-L1

A Phase III, randomized, Open-Label, multicenter study evaluating the efficacy and safety of Giredestrant plus Everolimus compared with Exemestane plus Everolimus in patients with estrogen receptor-positive, HER2-Negative, locally advanced or Metastatic Breast Cancer

WO43919 / INAVO121
A Phase III, Multicenter, Randomized, Open-Label Study Evaluating the efficacy and safety of Inavolisib plus Fulvestrant versus Alpelisib plus Fulvestrant in patients with Hormone Receptor Positive, HER-2-Negative, PIK3CA mutated, locally advanced or Metastatic Breast Cancer who progressed during or after CDK4/6 Inhibitor and Endocrine combination therapy



A Double-Blind, Placebo-Controlled, Randomized, Dose-Escalating, Multi-Center, Phase 1 Study to Assess the Safety and Tolerability of ART-123 in Combination with Leucovorin/5-Fluorouracil/Oxaliplatin and Bevacizumab in Metastatic Colorectal Cancer patients

MRT 849-010 / Krystal-10
A Randomized Phase 3 Study of MRTX849 in Combination with Cetuximab Versus Chemotherapy in Patients with Advanced Colorectal Cancer with KRAS G12C Mutation with Disease Progression On or After Standard First-Line Therapy


A Randomized, Double-Blind, International Multicenter, Phase III Study to Evaluate the Anti-Tumor Efficacy and Safety of HLX10 (Recombinant Humanized Anti-PD-1 Monoclonal Antibody Injection) or Placebo in Combination with Chemotherapy (Carboplatin/Cisplatin-Etoposide) and Concurrent Radiotherapy in Patients with Limited-Stage Small Cell Lung Cancer (LS-SCLC)

JZP 712-402
Emerge 402: Phase IV Observational Study to Collect Safety and Outcome data in Real-World Setting in Adult Patients with Extensive Stage Small Cell Lung Cancer (SCLC) Receiving Zepzelca

First Line Metastatic

GS-US-626-6216 / Star-121
A Randomized, Open-Label, Phase 3 Study to Evaluate Zimberelimaband Domvanalimab in Combination with Chemotherapy versus Pembrolizumab with Chemotherapy for the First-Line Treatment of Patients with Metastatic Non-Small Cell Lung Cancer with no Epidermal Growth Factor Receptor or Anaplastic Lymphoma Kinase Genomic Tumor Aberrations

Mirati 849-007
A Phase 2 Trial of MRTX849 in Combination with Pembrolizumab in Patients with Advanced non-Small Cell Lung Cancer with KRAS G12C Mutation

Second Line Metastatic

GSK 213410 ***Enrollment on Hold****
A Randomized, Open Label Phase 2/3 Study Comparing Cobolimab + Dostarlimab + Docetaxel to Dostarlimab + Docetaxel to Docetaxel Alone in Participants with Advanced Nonsmall Cell Lung Cancer who have Progressed on Prior Anti PD (L)1 Therapy and Chemotherapy (Costar Lung)


D8227C00001 / ACE-LY-312 / Escalade
A phase 3, Randomized, Double-Blind, Placebo-controlled study of Acalabrutinib in combination with Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Subjects 65 years or younger with previously untreated Non-Germinal Center Diffuse Large B-Cell Lymphoma

LOXO-BTK-20030  ***Screening of treatment naïve patients is closed***
A Phase 3 Open-Label, Randomized Study of Pirtobrutinib (LOXO-305) versus Ibrutinib in Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN-CLL-314)


Study of EOS884448 alone, and in combination with Iberdomide with or without Dexamethasone, in participants with relapsed or refactory Multiple Myeloma

Prostate Cancer

AstraZeneca D361BC00001 CAPItello-281
A Phase III Double-Blind, Randomized, Placebo-Controlled Study Assessing the Efficacy and Safety of Capivasertib + Abiraterone Versus Placebo + Abiraterone as Treatment for Patients with De Novo Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) Characterised by PTEN deficiency (CAPItello-281)

Solid Tumors

A Phase II Basket Study of Disitamab Vedotin in Adult Subjects with Previously Treated, Locally-Advanced Unresectable or Metastatic Solid Tumors that Express HER2

Supportive Care

Bespoke (Natera)
BESPOKE Study of ctDNA Guided Immunotherapy

FRNM-008 (Freenome)
A Case Control Study for the Development of Multiomics Blood Test for Cancer Screening

A randomized, Double-Blind, Double-dummy, Parallel Group Study to Assess the Efficacy and Safety of Palonosetron HCl Buccal Film versus IV Palonosetron 0.25 mg for the Prevention of Chemotherapy-induced Nausea and Vomiting in Cancer Patients Receiving Moderately Emetogenic Chemotherapy
THR-CS-001 / THRIVE / DETECT-ASCEND 2  ***Only Thyroid, Ovarian, Uterine and Bladder Cohorts Open***
Exact Sciences Thrive LLC / Detecting Cancers Earlier Through Elective Plasma-Based CancerSEEK Testing – Ascertaining Serial Cancer Patients to Enable New Diagnostic II (DETECT-ASCEND 2)

For more information on clinical trials, please contact Dr. Susan Johnson, Director of Research or 860-886-8362.  

To learn about phases of trials and what it means to participate, click here.

To learn about our newest study on biomarker testing, click here.

To learn about our newest study on bladder cancer, click here.